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This article introduces 3D segmentation, partitioning volumetric data into labeled regions for applications in medical imaging, robotics, and more. Focusing on 3D semantic segmentation, it uses the Swin UNETR architecture for brain tumor segmentation as an example. The article covers core concepts, training on the BraTS dataset including MRI normalization, input/output processing, computational challenges, and adapting Swin UNETR for 3D image classification.